deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
dC, Thy-dRib, dU + ATP → dCMP, TMP, dUMP + ADP + H+
- Reactome
- R-HSA-109759
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:46041, RHEA:19130, RHEA:28207
Inputs
- dC, Thy-dRib, dUR-ALL-500822, mitochondrial matrix
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
Outputs
- dCMP, TMP, dUMPR-ALL-500823, mitochondrial matrix
- ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- nucleoside kinase activity of TK2 [mitochondrial matrix]UniProt O00142
Literature
- Mammalian thymidine kinase 2. Direct photoaffinity labeling with [32P]dTTP of the enzyme from spleen, liver, heart and brain Eur J Biochem, 1992
- Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia J Biol Chem, 1976
- Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides J Biol Chem, 1991
- Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates FEBS Lett, 1999