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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Glycine & glyoxylate

Glycine cleavage, synthesis and glyoxylate detoxification across cytosolic, mitochondrial and peroxisomal contexts. 19 reactions, from Reactome R-HSA-389661.

glyoxylate + alanine => glycine + pyruvate [peroxisome]glyoxylate + L-Ala → Gly + PYR
glycine + O2 => glyoxylate + H2O2 + NH4+Gly + H2O + O2 → glyoxylate + H2O2 + NH4+
glyoxylate + NADPH + H+ => glycolate + NADP+glyoxylate + NADPH + H+ → NADP+ + glycolate
HAO1 tetramer oxidizes glycolate to glyoxylateglycolate + O2 → glyoxylate + H2O2
Conversion of glyoxylate to oxalateglyoxylate + H2O + O2 → OX + H2O2
PXLP-K754-GLDC dimer decarboxylates GlyGly + Lipo-K107-GCSH + H+ → CO2 + AmMeLipoGCSH:SAMDLL
AMT transfers NH2CH2 from GCSH:SAMDLL to THFAmMeLipoGCSH:SAMDLL + THF → GCSH:DHLL + 5,10-methylene-THF + NH4+
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoateGCSH:DHLL + NAD+ → Lipo-K107-GCSH + H+ + NADH
Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrixHPRO → HPRO
PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylateHPRO + quinone → 1PYR-3OH-5COOH + quinol + H+
PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)4OH-L-Glu + 2OG → HOG + L-Glu
ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate2 H2O + 1PYR-3OH-5COOH + NAD+ → 4OH-L-Glu + H+ + NADH
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvateHOG → glyoxylate + PYR
An unknown carrier transports cytosolic glyoxylate to the peroxisomeglyoxylate → glyoxylate
An unknown carrier transports mitochondrial glyoxylate to the cytosolglyoxylate → glyoxylate
GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARCAdoMet + Gly → AdoHcy + SARC + H+
DDO oxidizes D-Asp to OAD-Asp + H2O + O2 → OA + NH4+ + H2O2
PXMP2 trimer transports glycolate from cytosol to peroxisomal matrixglycolate → glycolate
Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvateL-Ala + glyoxylate → Gly + PYR