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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glyoxylate + NADPH + H+ => glycolate + NADP+

glyoxylate + NADPH + H+ → NADP+ + glycolate

Reactome: R-HSA-389826
Compartment: peroxisomal matrix
Rhea: RHEA:10994

Inputs

glyoxylateCHEBI:36655, C2HO3, peroxisomal matrix
NADPHCHEBI:57783, C21H26N7O17P3, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, peroxisomal matrix
glycolateCHEBI:29805, C2H3O3, peroxisomal matrix

Catalysed by

glyoxylate reductase (NADPH) activity of GRHPR [peroxisomal matrix]EC 1.1.1.79; UniProt Q9UBQ7

Literature

Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase Biochim Biophys Acta, 1999
The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II Hum Mol Genet, 1999