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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Conversion of glyoxylate to oxalate

glyoxylate + H2O + O2 → OX + H2O2

Reactome: R-HSA-389862
Compartment: peroxisomal matrix
Rhea: RHEA:14838

Inputs

glyoxylateCHEBI:36655, C2HO3, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix
O2CHEBI:15379, O2, peroxisomal matrix

Outputs

OXCHEBI:30623, C2O4, peroxisomal matrix
H2O2CHEBI:16240, H2O2, peroxisomal matrix

Catalysed by

glyoxylate oxidase activity of HAO1 tetramer [peroxisomal matrix]EC 1.2.3.5

Literature

Identification and expression of a cDNA for human glycolate oxidase Biochim Biophys Acta, 2000
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Biochemistry, 2008
Purification and characterization of recombinant human liver glycolate oxidase Arch Biochem Biophys, 2007
Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases J Biol Chem, 2000