PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate
HPRO + quinone → 1PYR-3OH-5COOH + quinol + H+
- Reactome
- R-HSA-6784224
- Compartment
- mitochondrial matrix · mitochondrial inner membrane
- Rhea
- RHEA:52513
Inputs
- HPROCHEBI:58375, C5H9NO3, mitochondrial matrix
- quinoneCHEBI:132124, C6O2R4, mitochondrial matrix
Outputs
- 1PYR-3OH-5COOHCHEBI:62612, C5H6NO3, mitochondrial matrix
- quinolCHEBI:24646, C6H2O2R4, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- proline dehydrogenase activity of PRODH2 dimer [mitochondrial inner membrane]EC 1.5.5.2
Literature
- Hydroxyproline metabolism. II. Enzymatic preparation and properties of Delta 1-pyrroline-3-hydroxy-5-carboxylic acid J. Biol. Chem., 1960
- Metabolism of proline and the hydroxyprolines Annu Rev Biochem, 1980
- Proteomic analysis of the mouse liver mitochondrial inner membrane J. Biol. Chem., 2003
- Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria Biochem. J., 2015