Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

GCSH:DHLL + NAD+ → Lipo-K107-GCSH + H+ + NADH

Reactome: R-HSA-5694018
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

GCSH:DHLLR-HSA-5693982, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

Lipo-K107-GCSHR-HSA-6793611, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix

Catalysed by

dihydrolipoyl dehydrogenase (NADH) activity of OGDH complex [mitochondrial matrix]EC 1.8.1.4

DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate

Inputs

Outputs

Catalysed by

Literature