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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DDO oxidizes D-Asp to OA

D-Asp + H2O + O2 → OA + NH4+ + H2O2

Reactome: R-HSA-6810076
Compartment: peroxisomal matrix
Rhea: RHEA:12513

Inputs

D-AspCHEBI:29990, C4H6NO4, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix
O2CHEBI:15379, O2, peroxisomal matrix

Outputs

OACHEBI:16452, C4H2O5, peroxisomal matrix
NH4+CHEBI:28938, H4N, peroxisomal matrix
H2O2CHEBI:16240, H2O2, peroxisomal matrix

Catalysed by

D-aspartate oxidase activity of DDO:FAD [peroxisomal matrix]EC 1.4.3.1

Literature

C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal Biochem. J., 1998
Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes Biol. Pharm. Bull., 2015
Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment Biochimie, 2010
The primary structure of the flavoprotein D-aspartate oxidase from beef kidney J. Biol. Chem., 1992
Structural and functional characterization of the human brain D-aspartate oxidase J. Biochem., 1997