glyoxylate + alanine => glycine + pyruvate [peroxisome]

glyoxylate + L-Ala → Gly + PYR

Reactome

R-HSA-389684

Compartment

peroxisomal matrix

Rhea

RHEA:24249

Catalysed by

• L-alanine:glyoxylate transaminase activity of AGXT dimer [peroxisomal matrix]EC 2.6.1.44

Literature

1. Overexpression of human alanine:glyoxylate aminotransferase in Escherichia coli: renaturation from guanidine-HCl and affinity for pyridoxal phosphate co-factor Protein Expr Purif, 2005
2. Further studies on the activity and subcellular distribution of alanine:glyoxylate aminotransferase in the livers of patients with primary hyperoxaluria type 1 Clin Sci (Lond), 1988
3. Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1 J Cell Biol, 1990
4. Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon Biochem J, 1990
5. Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1 J Mol Biol, 2003