HAO1 tetramer oxidizes glycolate to glyoxylate
glycolate + O2 → glyoxylate + H2O2
- Reactome
- R-HSA-389842
- Compartment
- peroxisomal matrix
- Rhea
- RHEA:25312
Inputs
- glycolateCHEBI:29805, C2H3O3, peroxisomal matrix
- O2CHEBI:15379, O2, peroxisomal matrix
Outputs
- glyoxylateCHEBI:36655, C2HO3, peroxisomal matrix
- H2O2CHEBI:16240, H2O2, peroxisomal matrix
Catalysed by
- (S)-2-hydroxy-acid oxidase activity of HAO1 tetramer [peroxisomal matrix]EC 1.1.3.15
Literature
- Identification and expression of a cDNA for human glycolate oxidase Biochim Biophys Acta, 2000
- Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Biochemistry, 2008
- Purification and characterization of recombinant human liver glycolate oxidase Arch Biochem Biophys, 2007
- Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases J Biol Chem, 2000