Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)

4OH-L-Glu + 2OG → HOG + L-Glu

Reactome: R-HSA-6784393
Compartment: mitochondrial matrix
Rhea: RHEA:31236

Inputs

4OH-L-GluCHEBI:6331, C5H8NO5, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Outputs

HOGCHEBI:62213, C5H4O6, mitochondrial matrix
L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix

Catalysed by

(4S)-4-hydroxy-L-glutamate:2-oxoglutarate transaminase activity of GOT2 dimer [mitochondrial matrix]EC 2.6.1.23

PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)

Inputs

Outputs

Catalysed by

Literature