Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AMT transfers NH2CH2 from GCSH:SAMDLL to THF

AmMeLipoGCSH:SAMDLL + THF → GCSH:DHLL + 5,10-methylene-THF + NH4+

Reactome: R-HSA-5693977
Compartment: mitochondrial matrix
Rhea: RHEA:16946

Inputs

AmMeLipoGCSH:SAMDLLR-HSA-5693969, mitochondrial matrix
THFCHEBI:57453, C19H21N7O6, mitochondrial matrix

Outputs

GCSH:DHLLR-HSA-5693982, mitochondrial matrix
5,10-methylene-THFCHEBI:15636, C20H21N7O6, mitochondrial matrix
NH4+CHEBI:28938, H4N, mitochondrial matrix

Catalysed by

aminomethyltransferase activity of AMT [mitochondrial matrix]EC 2.1.2.10; UniProt P48728

AMT transfers NH2CH2 from GCSH:SAMDLL to THF

Inputs

Outputs

Catalysed by

Literature