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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

HOG → glyoxylate + PYR

Reactome: R-HSA-6784423
Compartment: mitochondrial matrix
Rhea: RHEA:18170, RHEA:30688

Inputs

HOGCHEBI:62213, C5H4O6, mitochondrial matrix

Outputs

glyoxylateCHEBI:36655, C2HO3, mitochondrial matrix
PYRCHEBI:15361, C3H3O3, mitochondrial matrix

Catalysed by

(R,S)-4-hydroxy-2-oxoglutarate aldolase activity of HOGA1 tetramer [mitochondrial matrix]EC 4.1.3.16

Literature

Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria PLoS ONE, 2011