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Glutamate & glutamine
Interconversion of major amino-nitrogen carriers and their links to 2-oxoglutarate. 14 reactions, from Reactome R-HSA-8964539.
- glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]L-Glu + ATP + NADPH + H+ → L-Glu5S + NADP+ + ADP + Pi
- PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro1PYR-5COOH + 2 H+ + NADPH → L-Pro + NADP+
- PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro1PYR-5COOH + 2 H+ + NADPH → L-Pro + NADP+
- alpha-ketoglutarate + NH4+ + NAD(P)H + H+ glutamate + NAD(P)+ (GLUD1,2)2OG + NH4+ + NAD(P)H + H+ → L-Glu + NAD(P)+ + H2O
- glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)L-Glu + NAD(P)+ + H2O → 2OG + NH4+ + NAD(P)H + H+
- glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]ATP + L-Glu + NH4+ → ADP + L-Gln + Pi + H+
- glutamine + H2O => glutamate + NH4+ (GLS)H2O + L-Gln → L-Glu + NH4+
- GOT2 transaminates OA and L-GluOA + L-Glu → L-Asp + 2OG
- ornithine + alpha-ketoglutarate glutamate + L-glutamate gamma-semialdehyde [OAT]L-Orn + 2OG → L-Glu + L-Glu5S
- L-glutamate gamma-semialdehyde L-1-pyrroline-5-carboxylateL-Glu5S → 1PYR-5COOH + H2O + H+
- PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro1PYR-5COOH + 2 H+ + NADH → L-Pro + NAD+
- glutamate + L-glutamate gamma-semialdehyde ornithine + alpha-ketoglutarate [OAT]L-Glu + L-Glu5S → L-Orn + 2OG
- glutamine + pyruvate => 2-oxoglutaramate + alanineL-Gln + PYR → 2OGA + L-Ala
- N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAGL-Glu + ATP + NAASP → ADP + NAAG + H+ + Pi