glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
L-Glu + ATP + NADPH + H+ → L-Glu5S + NADP+ + ADP + Pi
- Reactome
- R-HSA-508040
- Compartment
- mitochondrial matrix · mitochondrial inner membrane
- Rhea
- RHEA:33208
Inputs
- L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Outputs
- L-Glu5SCHEBI:58066, C5H9NO3, mitochondrial matrix
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
- ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
- PiCHEBI:43474, HO4P, mitochondrial matrix
Catalysed by
- delta1-pyrroline-5-carboxylate synthetase activity of P5CS dimers [mitochondrial inner membrane]