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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutamine + H2O => glutamate + NH4+ (GLS)

H2O + L-Gln → L-Glu + NH4+

Reactome: R-HSA-70609
Compartment: mitochondrial matrix
Rhea: RHEA:15890

Inputs

H2OCHEBI:15377, H2O, mitochondrial matrix
L-GlnCHEBI:58359, C5H10N2O3, mitochondrial matrix

Outputs

L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
NH4+CHEBI:28938, H4N, mitochondrial matrix

Catalysed by

glutaminase activity of GLS dimers [mitochondrial matrix]EC 3.5.1.2

Literature

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing Physiol Genomics, 1999
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase Biochem J, 2000
Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells Biochem J, 1988