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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutamate + L-glutamate gamma-semialdehyde ornithine + alpha-ketoglutarate [OAT]

L-Glu + L-Glu5S → L-Orn + 2OG

Reactome: R-HSA-70666
Compartment: mitochondrial matrix
Rhea: RHEA:25162

Inputs

L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
L-Glu5SCHEBI:58066, C5H9NO3, mitochondrial matrix

Outputs

L-OrnCHEBI:46911, C5H13N2O2, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Catalysed by

L-ornithine transaminase activity of OAT hexamer [mitochondrial matrix]EC 2.6.1.13

Literature

Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences. J Biol Chem, 1992