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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG

L-Glu + ATP + NAASP → ADP + NAAG + H+ + Pi

Reactome: R-HSA-8942575
Compartment: cytosol
Rhea: RHEA:40036

Inputs

L-GluCHEBI:29985, C5H8NO4, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
NAASPCHEBI:16953, C6H7NO5, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
NAAGCHEBI:76931, C11H13N2O8, cytosol
H+CHEBI:15378, H, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

N-acetyl-L-aspartate-L-glutamate ligase activity of RIMKLA, RIMKLB [cytosol]

Literature

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase J. Biol. Chem., 2010