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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

1PYR-5COOH + 2 H+ + NADH → L-Pro + NAD+

Reactome: R-HSA-70664
Compartment: mitochondrial matrix
Rhea: RHEA:14107

Inputs

1PYR-5COOHCHEBI:17388, C5H6NO2, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix

Outputs

L-ProCHEBI:60039, C5H9NO2, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Catalysed by

pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]EC 1.5.1.2

Literature

Functional specialization in proline biosynthesis of melanoma PLoS ONE, 2012
Crystal structure of human pyrroline-5-carboxylate reductase J Mol Biol, 2006
Mutations in PYCR1 cause cutis laxa with progeroid features Nat Genet, 2009