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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

1PYR-5COOH + 2 H+ + NADPH → L-Pro + NADP+

Reactome: R-HSA-6783939
Compartment: cytosol
Rhea: RHEA:14111

Inputs

1PYR-5COOHCHEBI:17388, C5H6NO2, cytosol
2 H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

L-ProCHEBI:60039, C5H9NO2, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

pyrroline-5-carboxylate reductase activity of PYCR2 decamer [cytosol]EC 1.5.1.2

Literature

Functional specialization in proline biosynthesis of melanoma PLoS ONE, 2012
Crystal structure of human recombinant ornithine aminotransferase. J Mol Biol, 1998
Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. J Biol Chem, 1989
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination Am. J. Hum. Genet., 2015