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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutamine + pyruvate => 2-oxoglutaramate + alanine

L-Gln + PYR → 2OGA + L-Ala

Reactome: R-HSA-893616
Compartment: cytosol
Rhea: RHEA:10401

Inputs

L-GlnCHEBI:58359, C5H10N2O3, cytosol
PYRCHEBI:15361, C3H3O3, cytosol

Outputs

2OGACHEBI:16769, C5H6NO4, cytosol
L-AlaCHEBI:57972, C3H7NO2, cytosol

Catalysed by

L-glutamine:pyruvate transaminase activity of PXLP-KYAT1 dimer [cytosol]EC 2.6.1.15

Literature

Purification and characterization of kynurenine aminotransferase I from human brain J Neurochem, 1994
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J Med Chem, 2009
Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase FEBS Lett, 1995
Crystal structure of human kynurenine aminotransferase I J Biol Chem, 2004