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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

1PYR-5COOH + 2 H+ + NADPH → L-Pro + NADP+

Reactome
R-HSA-6783955
Compartment
cytosol
Rhea
RHEA:14111

Inputs

Outputs

Catalysed by

  • pyrroline-5-carboxylate reductase activity of PYCR3 decamer [cytosol]EC 1.5.1.2

Literature

  1. Functional specialization in proline biosynthesis of melanoma PLoS ONE, 2012
  2. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. J Biol Chem, 1989