alpha-ketoglutarate + NH4+ + NAD(P)H + H+ glutamate + NAD(P)+ (GLUD1,2)
2OG + NH4+ + NAD(P)H + H+ → L-Glu + NAD(P)+ + H2O
- Reactome
- R-HSA-70589
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:15135, RHEA:11614
Inputs
- 2OGCHEBI:16810, C5H4O5, mitochondrial matrix
- NH4+CHEBI:28938, H4N, mitochondrial matrix
- NAD(P)HR-ALL-517496, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Outputs
- L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
- NAD(P)+R-ALL-517495, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Catalysed by
- L-glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]EC 1.4.1.3
Literature
- Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations Biochem J, 2002
- Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme J Biol Chem, 1979
- The structure of apo human glutamate dehydrogenase details subunit communication and allostery J Mol Biol, 2002