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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

ATP + L-Glu + NH4+ → ADP + L-Gln + Pi + H+

Reactome: R-HSA-70606
Compartment: cytosol
Rhea: RHEA:16170

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol
NH4+CHEBI:28938, H4N, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
L-GlnCHEBI:58359, C5H10N2O3, cytosol
PiCHEBI:43474, HO4P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

glutamine synthetase activity of GLUL decamer [cytosol]EC 6.3.1.2

glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

Inputs

Outputs

Catalysed by

Literature