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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Pyrimidine catabolism

Source-linked pyrimidine breakdown. 17 reactions, from Reactome R-HSA-73621.

  1. CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]CMP, TMP, UMP + H2O → Cyt-Rib, Thy-dRib, Ura-Rib + Pi
  2. (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi
  3. (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)(d)CMP, TMP, (d)UMP + H2O → (d)C, T, (d)U + Pi
  4. TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]TMP, U2MP, U3MP, UMP, dU3MP, dUMP + H2O → Thy-Rib, (d)U + Pi
  5. TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]TMP, UMP, dU5MP, U2MP, U3MP + H2O → Thy-dRib, Ura-Rib, dU + Pi
  6. thymidine or deoxyuridine + orthophosphate thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]Thy-Rib, dU + Pi → Thy, Ura + dRibP
  7. reduction of uracil to form dihydrouracilUra + NADPH + H+ → 5,6-Dihydrouracil + NADP+
  8. conversion of 5,6-dihydrouracil to 3-ureidopropionate5,6-Dihydrouracil + H2O → UPROP + H+
  9. conversion of 3-ureidopropionate to beta-alanineUPROP + H2O + 2 H+ → b-Ala + CO2 + NH4+
  10. reduction of thymine to form 5,6-DihydrothymineThy + NADPH + H+ → 5,6-Dihydrothymine + NADP+
  11. conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate5,6-Dihydrothymine + H2O → UIBA + H+
  12. conversion of 3-Ureidoiosbutyrate to 3-AminoisobutyrateUIBA + H2O + 2 H+ → CO2 + NH4+ + 3AIB
  13. (deoxy)uridine + orthophosphate uracil + (deoxy)ribose 1-phosphate (UPP)(d)Ura + Pi → Ura + R1P, dRibP
  14. Mitochondrial uptake of (R)-3-aminoisobutyric acid3AIB → 3AIB
  15. Mitochondrial uptake of beta-alanineb-Ala → b-Ala
  16. beta-alanine + pyruvate => 3-oxopropanoate + alanineb-Ala + PYR → OPROP + L-Ala
  17. (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine3AIB + PYR → L-Ala + 2-methyl-3-oxopropanoate