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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Very long-chain fatty acyl-CoAs

Source-linked very long-chain acyl-CoA synthesis. 12 reactions, from Reactome R-HSA-75876.

  1. ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoAATP + CoA-SH + PALM → AMP + H2O + PALM-CoA + PPi
  2. ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoAAA-CoA + Mal-CoA + H+ → 3ODCT-CoA + CoA-SH + CO2
  3. ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoAPALM-CoA + Mal-CoA + H+ → 3OOD-CoA + CoA-SH + CO2
  4. ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoAICS-CoA + Mal-CoA + H+ → CoA-SH + CO2 + 3ODC-CoA
  5. HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA3OOD-CoA + NADPH + H+ → 3HODC-CoA + NADP+
  6. ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoATCS-CoA + Mal-CoA + H+ → 3OHC-CoA + CoA-SH + CO2
  7. TECR,TECRL dehydrogenate TOD-CoA to ST-CoATOD-CoA + NADPH + H+ → ST-CoA + NADP+
  8. ACSL3,4 ligate CoA to AA to form AA-CoAAA + ATP + CoA-SH → AA-CoA + AMP + PPi + H2O
  9. PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoAVLC3HA-CoA → 2,3-TE-CoA + H2O
  10. ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  11. ACSF3 ligates CoA-SH to VLCFAVLCFA + ATP + CoA-SH → VLCFA-CoA + AMP + PPi
  12. SLC27A3 ligates CoA-SH to VLCFAATP + CoA-SH + VLCFA → VLCFA-CoA + AMP + PPi