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Tryptophan catabolism
Kynurenine-pathway and related reactions that distribute tryptophan carbon and nitrogen among several products. 18 reactions, from Reactome R-HSA-71240.
- IDO1 dioxygenates L-Trp to NFKL-Trp + O2 → NFK
- SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosolligands of SLC7A5 → ligands of SLC7A5
- TDO tetramer dioxygenates L-Trp to NFKL-Trp + O2 → NFK
- AFMID hydrolyses NFK to L-KYNNFK + H2O → L-KYN + HCOOH + H+
- kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2OL-KYN + O2 + NADPH + H+ → 3HKYN + NADP+ + H2O
- 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+3HKYN + H2O → 3HAA + L-Ala + H+
- 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde3HAA + O2 → ACS
- 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2ACS + H+ → 2AMA + CO2
- 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+2AMA + NAD+ + H2O → 2AM + NADH + H+
- SLC36A4 transports L-Trp from extracellular region to cytosolL-Trp → L-Trp
- IDO2 dioxygenates L-Trp to NFKL-Trp + O2 → NFK
- kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamateL-KYN + 2OG → APDBA + L-Glu
- PXLP-KYAT1 dimer transaminates L-KYN to KYNAL-KYN + 2OG → KYNA + L-Glu + H2O
- 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]APDBA → KYNA + H2O
- PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNAL-KYN + 2OG → KYNA + L-Glu + H2O
- 2AMA spontaneously forms picolinate2AMA → H+ + H2O + picolinate
- Unknown NAT N-acetylates kynurenineAc-CoA + L-KYN → N-acetylkynurenine + CoA-SH + H+
- AADAT transaminates 3HKYN to xanthurenate3HKYN + glyoxylate → xanthurenate + Gly + H2O