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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC36A4 transports L-Trp from extracellular region to cytosol

L-Trp → L-Trp

Reactome: R-HSA-8870352
Compartment: plasma membrane · extracellular region · cytosol
Rhea: RHEA:70947

Inputs

L-TrpCHEBI:57912, C11H12N2O2, extracellular region

Outputs

L-TrpCHEBI:57912, C11H12N2O2, cytosol

Catalysed by

L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane]UniProt Q6YBV0

Literature

Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 EMBO Rep., 2013
SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes J. Biol. Chem., 2011