PXLP-KYAT1 dimer transaminates L-KYN to KYNA
L-KYN + 2OG → KYNA + L-Glu + H2O
- Reactome
- R-HSA-893596
- Compartment
- cytosol
- Rhea
- RHEA:65561
Inputs
- L-KYNCHEBI:57959, C10H12N2O3, cytosol
- 2OGCHEBI:16810, C5H4O5, cytosol
Outputs
- KYNACHEBI:58454, C10H6NO3, cytosol
- L-GluCHEBI:29985, C5H8NO4, cytosol
- H2OCHEBI:15377, H2O, cytosol
Catalysed by
- L-kynurenine:2-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol]EC 2.6.1.7
Literature
- Purification and characterization of kynurenine aminotransferase I from human brain J Neurochem, 1994
- Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K J Med Chem, 2009
- The transamination of kynurenine J Biol Chem, 1953
- Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase FEBS Lett, 1995
- Crystal structure of human kynurenine aminotransferase I J Biol Chem, 2004