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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate

L-KYN + 2OG → APDBA + L-Glu

Reactome: R-HSA-893583
Compartment: mitochondrial matrix
Rhea: RHEA:20965

Inputs

L-KYNCHEBI:57959, C10H12N2O3, mitochondrial matrix
2OGCHEBI:16810, C5H4O5, mitochondrial matrix

Outputs

APDBACHEBI:58147, C10H8NO4, mitochondrial matrix
L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix

Catalysed by

L-kynurenine:2-oxoglutarate transaminase activity of AADAT dimer [mitochondrial matrix]EC 2.6.1.7

Literature

Crystal structure of human kynurenine aminotransferase II J Biol Chem, 2008
The transamination of kynurenine J Biol Chem, 1953