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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

L-KYN + O2 + NADPH + H+ → 3HKYN + NADP+ + H2O

Reactome: R-HSA-71200
Compartment: cytosol
Rhea: RHEA:20546

Inputs

L-KYNCHEBI:57959, C10H12N2O3, cytosol
O2CHEBI:15379, O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

3HKYNCHEBI:58125, C10H12N2O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

kynurenine 3-monooxygenase activity of KMO [mitochondrial outer membrane]EC 1.14.13.9; UniProt O15229

Literature

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase Eur J Biochem, 2000
On the submitochondrial localization of l-kynurenine-3-hydroxylase Biochem Biophys Res Commun, 1967