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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+

2AMA + NAD+ + H2O → 2AM + NADH + H+

Reactome: R-HSA-71239
Compartment: cytosol
Rhea: RHEA:14470

Inputs

2AMACHEBI:77634, C6H7NO3, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

2AMCHEBI:77859, C6H6NO4, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

aminomuconate-semialdehyde dehydrogenase activity of AM-SHDH [cytosol]EC 1.2.1.32

Literature

Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymatic formation of alpha-muconic acid from 2-hydroxyanthranilic acid J Biol Chem, 1965