NUCLEOTIDES

Nucleotide economy

Construction, interconversion, salvage and breakdown of purine and pyrimidine nucleotides.

NUCLEOTIDES7 pathway backbones

Nucleotide biosynthesis24 represented events · source Nucleotide salvage22 represented events · source Nucleotide catabolism63 represented events · source Di-/triphosphate interconversion34 represented events · source Purine catabolism33 represented events · source Pyrimidine catabolism17 represented events · source Pyrimidine salvage10 represented events · source

These routes occupy a stable territory in the publication map and link to their source records for closer inspection.

Purine and pyrimidine nucleotides are built by different architectural strategies. Purine atoms are assembled stepwise on a ribose-phosphate scaffold, whereas a pyrimidine ring is largely constructed before attachment to ribose phosphate.

Salvage pathways recover bases and nucleosides at lower synthetic cost, while catabolic pathways dephosphorylate, deaminate, cleave and oxidize them. The balance among synthesis, salvage and degradation depends on cell context and substrate availability.

Nucleoside diphosphate kinases and related phosphate-transfer reactions connect nucleotide pools. The map keeps individual base identities visible rather than treating ATP as a generic synonym for every nucleoside triphosphate.

Ideas to carry into the map

De novo synthesis and salvage solve different supply problems.
Purine and pyrimidine rings follow different construction logic.
Nucleotide pools are continually interconverted.

Pathways in this field note

Nucleotide biosynthesisR-HSA-8956320 · 24 represented events

De novo purine and pyrimidine pathways that build bases on or attach them to ribose-phosphate scaffolds.

On the map Reactome source

Nucleotide salvageR-HSA-8956321 · 22 represented events

Recovery of bases and nucleosides into reusable nucleotide pools.

On the map Reactome source

Nucleotide catabolismR-HSA-8956319 · 63 represented events

Dephosphorylation, deamination, cleavage and oxidation routes for purines and pyrimidines.

On the map Reactome source

Di-/triphosphate interconversionR-HSA-499943 · 34 represented events

Phosphate-transfer reactions that balance nucleoside diphosphate and triphosphate pools.

On the map Reactome source

Purine catabolismR-HSA-74259 · 33 represented events

Source-linked purine breakdown.

On the map Reactome source

Pyrimidine catabolismR-HSA-73621 · 17 represented events

Source-linked pyrimidine breakdown.

On the map Reactome source

Pyrimidine salvageR-HSA-73614 · 10 represented events

Source-linked pyrimidine recovery.

On the map Reactome source

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