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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Pyrimidine salvage

Source-linked pyrimidine recovery. 10 reactions, from Reactome R-HSA-73614.

deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]dC, Thy-dRib, dU + ATP → dCMP, TMP, dUMP + ADP + H+
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]Cyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
thymine or uracil + 2-deoxy-D-ribose 1-phosphate thymidine or deoxyuridine + orthophosphate [TYMP]Thy, Ura + dRibP → Thy-Rib, dU + Pi
HDHD1:Mg2+ dephosphorylates PURIDPPURIDP + H2O → PURID + Pi
(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)Cyt-Rib, dC + ATP → (d)CMP + ADP + H+
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]Cyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+
deamination of 2'-Deoxycytidine to 2'-DeoxyuridineCyt-Rib, dC + H2O + H+ → (d)Ura + NH4+
phosphorylation of 2'-Deoxythymidine to dTMPThy-dRib + ATP → TMP + ADP + H+
uracil + (deoxy)ribose 1-phosphate (deoxy)uridine + orthophosphate [UPP]Ura + R1P, dRibP → (d)Ura + Pi
UCKL1 phosphorylates urindine, cytidineCyt-Rib, Ura-Rib + ATP → CMP, UMP + ADP + H+