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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Lysine catabolism

Source-linked human lysine catabolism. 16 reactions, from Reactome R-HSA-71064.

  1. 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]2OG + 2-OA → 2OG + 2-OA
  2. alpha-ketoadipate + glutamate alpha-aminoadipate + alpha-ketoglutarateL-Glu + 2-OA → 2OG + 2AMA
  3. CRYM reduces P2C to PPCAP2C + H+ + NADPH → PPCA + NADP+
  4. PXLP-K278-PHYKPL tetramer hydrolyses 5PHL5PHL + H2O → 2AMAS + Pi + NH4+
  5. PIPOX oxidises PPCA to P6CPPCA + O2 → P6C + H2O2 + H+
  6. P6C transforms to 2AMASP6C + H2O + H+ → 2AMAS
  7. HYKK phosphorylates 5HLYS5HLYS + GTP → 5PHL + GDP + H+
  8. lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2OL-Lys + 2OG + NADPH + H+ → SACN + NADP+ + H2O
  9. saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+SACN + NAD+ + H2O → 2AMAS + L-Glu + NADH + H+
  10. alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+2AMAS + NAD+ + H2O → 2AMA + NADH + 2 H+
  11. alpha-aminoadipate + alpha-ketoglutarate alpha-ketoadipate + glutamate2OG + 2AMA → L-Glu + 2-OA
  12. glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2FAD + GL-CoA + 2 H+ → crotonyl-CoA + FADH2 + CO2
  13. DHTKD1 dimer decarboxylates 2-OAH+ + Lipo-K110-DLST + 2-OA → CO2 + GlutaryllipoH2-K110-DLST
  14. DLD dimer dehydrogenates dihydrolipoylNAD+ + LipoH2-K110-DLST → H+ + NADH + Lipo-K110-DLST
  15. DLST transfers glutaryl to CoACoA-SH + GlutaryllipoH2-K110-DLST + H+ → LipoH2-K110-DLST + GL-CoA
  16. 2AMAS transport from peroxisome to mitochondrial matrix2AMAS → 2AMAS