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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HYKK phosphorylates 5HLYS

5HLYS + GTP → 5PHL + GDP + H+

Reactome: R-HSA-6788611
Compartment: mitochondrial matrix
Rhea: RHEA:19050

Inputs

5HLYSCHEBI:58357, C6H15N2O3, mitochondrial matrix
GTPCHEBI:37565, C10H12N5O14P3, mitochondrial matrix

Outputs

5PHLCHEBI:57882, C6H14N2O6P, mitochondrial matrix
GDPCHEBI:58189, C10H12N5O11P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

hydroxylysine kinase activity of HYKK [mitochondrial matrix]EC 2.7.1.81; UniProt A2RU49

Literature

Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine J. Biol. Chem., 2012