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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DLST transfers glutaryl to CoA

CoA-SH + GlutaryllipoH2-K110-DLST + H+ → LipoH2-K110-DLST + GL-CoA

Reactome: R-HSA-9858590
Compartment: mitochondrial matrix
Rhea: RHEA:18011

Inputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
GlutaryllipoH2-K110-DLSTR-HSA-9858581, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

LipoH2-K110-DLSTR-HSA-9853485, mitochondrial matrix
GL-CoACHEBI:57378, C26H37N7O19P3S, mitochondrial matrix

Catalysed by

peptide glutaryltransferase activity of OADH complex [mitochondrial matrix]

Literature

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas Am J Hum Genet, 2019
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species Free Radic Biol Med, 2018