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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]

2OG + 2-OA → 2OG + 2-OA

Reactome: R-HSA-372480
Compartment: mitochondrial matrix · mitochondrial inner membrane · cytosol
Rhea: RHEA:71739

Inputs

2OGCHEBI:16810, C5H4O5, mitochondrial matrix
2-OACHEBI:57499, C6H6O5, cytosol

Outputs

2OGCHEBI:16810, C5H4O5, cytosol
2-OACHEBI:57499, C6H6O5, mitochondrial matrix

Catalysed by

alpha-ketoglutarate transmembrane transporter activity of SLC25A21 [mitochondrial inner membrane]UniProt Q9BQT8

Literature

Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location J Biol Chem, 2001