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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

alpha-ketoadipate + glutamate alpha-aminoadipate + alpha-ketoglutarate

L-Glu + 2-OA → 2OG + 2AMA

Reactome: R-HSA-508561
Compartment: mitochondrial matrix
Rhea: RHEA:12603

Inputs

L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
2-OACHEBI:57499, C6H6O5, mitochondrial matrix

Outputs

2OGCHEBI:16810, C5H4O5, mitochondrial matrix
2AMACHEBI:58672, C6H10NO4, mitochondrial matrix

Catalysed by

L-2-aminoadipate:2-oxoglutarate transaminase activity of AADAT dimer [mitochondrial matrix]EC 2.6.1.39

Literature

Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). Mol Genet Metab, 2002
Crystal structure of human kynurenine aminotransferase II J Biol Chem, 2008
Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia J Biol Chem, 2008