alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
2AMAS + NAD+ + H2O → 2AMA + NADH + 2 H+
- Reactome
- R-HSA-70941
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:12309
Inputs
- 2AMASCHEBI:58321, C6H11NO3, mitochondrial matrix
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- 2AMACHEBI:58672, C6H10NO4, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
- 2 H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity of ALDH7A1 tetramer [mitochondrial matrix]EC 1.2.1.31
Literature
- Mutations in antiquitin in individuals with pyridoxine-dependent seizures Nat Med, 2006
- Is antiquitin a mitochondrial Enzyme? J Cell Biochem, 2010