Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2

FAD + GL-CoA + 2 H+ → crotonyl-CoA + FADH2 + CO2

Reactome: R-HSA-71046
Compartment: mitochondrial matrix
Rhea: RHEA:30848

Inputs

FADCHEBI:57692, C27H30N9O15P2, mitochondrial matrix
GL-CoACHEBI:57378, C26H37N7O19P3S, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix

Outputs

crotonyl-CoACHEBI:57332, C25H36N7O17P3S, mitochondrial matrix
FADH2CHEBI:58307, C27H33N9O15P2, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix

Catalysed by

glutaryl-CoA dehydrogenase activity of GCDH tetramer [mitochondrial matrix]EC 1.3.8.6

glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2

Inputs

Outputs

Catalysed by

Literature