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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CRYM reduces P2C to PPCA

P2C + H+ + NADPH → PPCA + NADP+

Reactome: R-HSA-5693347
Compartment: peroxisomal matrix
Rhea: RHEA:12526

Inputs

P2CCHEBI:77631, C6H9NO2, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix
NADPHCHEBI:57783, C21H26N7O17P3, peroxisomal matrix

Outputs

PPCACHEBI:61185, C6H11NO2, peroxisomal matrix
NADP+CHEBI:58349, C21H25N7O17P3, peroxisomal matrix

Catalysed by

delta1-piperideine-2-carboxylate reductase activity of CRYM [peroxisomal matrix]EC 1.5.1.21; UniProt Q14894

Literature

Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions Neurochem. Res., 2015
Crystal structure of human micro-crystallin complexed with NADPH Protein Sci., 2007