Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Histidine catabolism

Source-linked human histidine catabolism. 10 reactions, from Reactome R-HSA-70921.

HNMT transfers CH3 group from AdoMet to HistHist + AdoMet → AdoHcy + MeHist + H+
CARNS1 transforms ATP, L-His, b-Ala to CARNATP + L-His + b-Ala → CARN + ADP + Pi + H+
histidine => urocanate + NH4+L-His → UCA + NH4+
urocanate + H2O => 4-imidazolone-5-propanoateUCA + H2O → 4I-5PROA
4-imidazolone-5-propanoate + H2O => N-formiminoglutamate4I-5PROA + H2O → NF-Glu
N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolateNF-Glu + THF → L-Glu + FITHF
CARNMT1 methylates CARN to AnserineCARN + AdoMet → Anserine + AdoHcy + H+
Histidine is decarboxylated to histamineL-His + H+ → Hist + CO2
AOC1 dimer oxidizes MeHistH2O + MeHist + O2 → methylimidazole-aldehyde + H2O2 + NH4+
Unknown ALDH oxidizes methylimidazolealdehydemethylimidazole-aldehyde + H2O + NAD(P)+ → 2 H+ + NAD(P)H + methylimidazole-acetate