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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CARNS1 transforms ATP, L-His, b-Ala to CARN

ATP + L-His + b-Ala → CARN + ADP + Pi + H+

Reactome: R-HSA-6786245
Compartment: cytosol
Rhea: RHEA:19298

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
L-HisCHEBI:57595, C6H9N3O2, cytosol
b-AlaCHEBI:57966, C3H7NO2, cytosol

Outputs

CARNCHEBI:57485, C9H14N4O3, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

carnosine synthase activity of CARNS1 [cytosol]EC 6.3.2.11; UniProt A5YM72

Literature

Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1) J. Biol. Chem., 2010