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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AOC1 dimer oxidizes MeHist

H2O + MeHist + O2 → methylimidazole-aldehyde + H2O2 + NH4+

Reactome: R-HSA-9970023
Compartment: cytosol
Rhea: RHEA:78368

Inputs

H2OCHEBI:15377, H2O, cytosol
MeHistCHEBI:58600, C6H12N3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

methylimidazole-aldehydeCHEBI:28104, C6H8N2O, cytosol
H2O2CHEBI:16240, H2O2, cytosol
NH4+CHEBI:28938, H4N, cytosol

Catalysed by

histamine oxidase activity of AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane]EC 1.4.3.22

Literature

Human kidney diamine oxidase: heterologous expression, purification, and characterization J Biol Inorg Chem, 2002