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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

4-imidazolone-5-propanoate + H2O => N-formiminoglutamate

4I-5PROA + H2O → NF-Glu

Reactome: R-HSA-70906
Compartment: cytosol
Rhea: RHEA:23661

Inputs

4I-5PROACHEBI:77893, C6H7N2O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

NF-GluCHEBI:58928, C6H9N2O4, cytosol

Catalysed by

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides of AMDHD1 [cytosol]EC 3.5.2; UniProt Q96NU7

Literature

Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas Oncogene, 2004