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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HNMT transfers CH3 group from AdoMet to Hist

Hist + AdoMet → AdoHcy + MeHist + H+

Reactome: R-HSA-175993
Compartment: cytosol
Rhea: RHEA:19302

Inputs

HistCHEBI:58432, C5H10N3, cytosol
AdoMetCHEBI:59789, C15H23N6O5S, cytosol

Outputs

AdoHcyCHEBI:57856, C14H20N6O5S, cytosol
MeHistCHEBI:58600, C6H12N3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

histamine N-methyltransferase activity of HNMT [cytosol]EC 2.1.1.8; UniProt P50135

Literature

Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway Am. J. Physiol., 1994
Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons Structure, 2001
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics Biochemistry, 2008