urocanate + H2O => 4-imidazolone-5-propanoate

UCA + H2O → 4I-5PROA

Reactome

R-HSA-70903

Compartment

cytosol

Rhea

RHEA:13103

Catalysed by

• urocanate hydratase activity of UROC1:NAD+ [cytosol]EC 4.2.1.49

Literature

1. Mutations in the urocanase gene UROC1 are associated with urocanic aciduria J Med Genet, 2009
2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas Oncogene, 2004