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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

NF-Glu + THF → L-Glu + FITHF

Reactome: R-HSA-70920
Compartment: cytosol
Rhea: RHEA:15099

Inputs

NF-GluCHEBI:58928, C6H9N2O4, cytosol
THFCHEBI:57453, C19H21N7O6, cytosol

Outputs

L-GluCHEBI:29985, C5H8NO4, cytosol
FITHFCHEBI:57456, C20H22N8O6, cytosol

Catalysed by

formimidoyltetrahydrofolate cyclodeaminase activity of FTCD octamer [cytosol]EC 4.3.1.4

Literature

The molecular basis of glutamate formiminotransferase deficiency Hum Mutat, 2003
The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli. J Biol Chem, 1993
Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. Cytogenet Cell Genet, 2000