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Triglyceride metabolism
Assembly and hydrolysis of neutral-lipid stores and their exchange with glycerolipid intermediates. 24 reactions, from Reactome R-HSA-8979227.
- diacylglycerol + H2O -> 2-acylglycerol + fatty acidDAG + H2O → 2-acylglycerol + LCFA(-) + H+
- hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADPLIPE + 2 ATP → p-S950,S951-LIPE + 2 ADP
- perilipin + 2 ATP -> phosphorylated perilipin + 2 ADPPLIN1 + 2 ATP → p-S81,S277-PLIN1 + 2 ADP
- cholesterol ester + H2O -> cholesterol + fatty acidCHEST + H2O → CHOL + LCFA(-) + H+
- phosphorylated HSL + H2O -> HSL + orthophosphatep-S950,S951-LIPE + H2O → LIPE + Pi
- perilipin:ABHD5 complex -> perilipin + ABHD5perilipin:ABHD5 complex → ABHD5 + PLIN1
- phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complexFABP4 + phosphorylated HSL dimer → phosphorylated HSL dimer:FABP4 complex
- triacylglycerol + H2O -> diacylglycerol + fatty acidTAG + H2O → DAG + LCFA(-) + H+
- Phosphorylated HSL dimer translocates from the cytosol to the lipid particlephosphorylated HSL dimer → phosphorylated HSL dimer
- phosphorylated perilipin + H2O -> perilipin + orthophosphatep-S81,S277-PLIN1 + H2O → PLIN1 + Pi
- 2-acylglycerol + H2O -> glycerol + fatty acid2-acylglycerol + H2O → Glycerol + LCFA(-) + H+
- 2 phosphorylated HSL monomers -> phosphorylated HSL dimer2 p-S950,S951-LIPE → phosphorylated HSL dimer
- Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)G3P + FAD → DHAP + FADH2
- FABPs bind LCFAsFABPs + LCFA(-) → FABPs:LCFA
- 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]DAG + FACoA → TAG + CoA-SH
- AGMO cleaves alkylglycerol into fatty aldehyde and glycerolalkylglycerol + O2 + BH4 → fatty aldehyde + Glycerol + H2O + q-BH2
- MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG2AG + acyl-CoA → DAG + CoA-SH
- glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]G3P + FACoA → 1-acyl LPA + CoA-SH
- Conversion of Glycerol to Glycerol-3-phosphateGlycerol + ATP → G3P + ADP
- 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate1,2-daG3P + H2O → DAG + Pi
- 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]DAG + FACoA → TAG + CoA-SH
- PNPLA4 hydrolyzes TAGTAG + H2O → DAG + LCFA(-) + H+
- PNPLA5 hydrolyzes TAGTAG + H2O → DAG + LCFA(-) + H+
- PNPLA4 hydrolyzes retinyl palmitateatR-PALM + H2O → atROL + PALM(-) + H+