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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]

G3P + FACoA → 1-acyl LPA + CoA-SH

Reactome: R-HSA-75886
Compartment: cytosol · mitochondrial outer membrane
Rhea: None recorded

Inputs

G3PCHEBI:57597, C3H7O6P, cytosol
FACoACHEBI:77636, C22H31N7O17P3SR, cytosol

Outputs

1-acyl LPACHEBI:16975, C4H8O7PR, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

glycerol-3-phosphate O-acyltransferase activity of GPAM or GPAT2 [mitochondrial outer membrane]EC 2.3.1.15

Literature

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase J Biol Chem, 2008
Acyl-CoA:lysophospholipid acyltransferases J Biol Chem, 2009
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis Am J Physiol Endocrinol Metab, 2009